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Westlake Chemical Biology Frontiers Colloquium| Christopher J. Chang: Activity-based sensing: leveraging chemical reactivity for selective bioimaging

时间

2024年5月17日(周五)
16:00-17:30

地点

西湖大学云谷菲律宾纸飞机聊天app 学术环E10-201教室

主持

西湖大学理学院PI 张鑫教授

受众

全体师生

分类

学术与研究

Westlake Chemical Biology Frontiers Colloquium| Christopher J. Chang: Activity-based sensing: leveraging chemical reactivity for selective bioimaging

时间2024517日(周五)16:00-17:30

Time16:00-17:30, Friday, May 17, 2024

主持人: 西湖大学理学院PI 张鑫教授

Host: Prof. Xin Zhang, PI of School of Science, Westlake University

地址:西湖大学云谷菲律宾纸飞机聊天app 学术环E10-201教室

Venue: Lecture Hall E10-201, Yungu Campus, Westlake University


Prof. Christopher J. Chang

Departments of Chemistry and Molecular and Cell Biology

University of California, Berkeley


主讲人/Speaker

Chris Chang is the Class of 1942 Chair Professor in the Departments of Chemistry and Molecular and Cell Biology at UC Berkeley, and Faculty Scientist at Lawrence Berkeley National Laboratory. He completed his B.S. and M.S. degrees from Caltech in 1997, working with Harry Gray, and spent a year as a Fulbright scholar in Strasbourg, France with Nobel Laureate Jean-Pierre Sauvage. Chris earned his Ph.D. from MIT in 2002 working with Dan Nocera and stayed at MIT as a Jane Coffin Childs postdoctoral fellow with Steve Lippard, working on zinc biology and then began his independent career at UC Berkeley in 2004. His group will move to Princeton University in Summer 2024.

Research in the Chang laboratory focuses on the study of metals in biology and energy. His group has pioneered the concept of activity-based sensing, showing that selectivity in sensor design is achievable by reaction-based methods that go beyond traditional receptors that operate by lock-and-key binding. His work has changed dogma in the inorganic and chemical biology communities by showing that transition metals are not merely active site cofactors in proteins but can also serve as dynamic, allosteric regulators of protein function through metalloallostery, launching a field of transition metal signaling. Chris has published 250 papers (h-index 119) with 17 issued patents, and has given nearly 400 invited lectures worldwide. He has mentored 43 graduate students, 55 postdocs, 50 undergraduates, and 45 visiting scholars in his laboratory, with 45 former group alumni now in independent faculty positions.

Chris’s research group has been honored by awards from the Dreyfus, Beckman, Sloan, and Packard Foundations, Amgen, Astra Zeneca, and Novartis, AFAR, MIT Technology Review (TR35 Award), ACS (Cope Scholar, Eli Lilly Award, Baekeland), RSC (Transition Metal Chemistry, Jeremy Knowles Awards), and the Society for Biological Inorganic Chemistry. Included are the 2013 Noyce Prize at UC Berkeley for Excellence in Undergraduate Teaching, 2013 ACS Nobel Laureate Signature Award in Graduate Education, 2015 Blavatnik National Award in Chemistry, 2017 election to the American Academy of Arts and Sciences, 2019 Sackler Prize, 2020 Humboldt Award, 2021 Guggenheim Fellowship, and 2024 ACS Bader Award in Bioinorganic and Bioorganic Chemistry. He is Editor-in-Chief of Accounts of Chemical Research. More information on the Chang laboratory can be found at https://changlabucb.wordpress.com/.


讲座摘要/Abstract:

Traditional strategies for developing selective imaging reagents rely on molecular recognition and static lock-and-key binding to achieve high specificity. We are advancing an alternative approach to chemical probe design, termed activity-based sensing, in which we exploit inherent differences in chemical reactivity as a foundation for distinguishing between chemical analytes that are similar in shape and size within complex biological systems. This presentation will focus on activity-based sensing to visualize dynamic fluxes of metal ions, reactive oxygen species, and reactive carbon species, along with activity-based proteomics probes to characterize targets of single-atom signaling. In one example, we have identified a new paradigm termed metalloallostery, where metal binding beyond active sites at allosteric exosites in proteins can regulate fundamental behaviors such as eating and sleeping.


讲座联系人/Contact:

理学院,梁老师,邮箱:[email protected]

School of Science, Ms. Liang, Email: [email protected]

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